Modulation of immune responses by food ingredients 

Development of functional foods using underutilized fishery resources

Lee Y, Yoshitsugu R, Kikuchi K, Joe GH, Tsuji M, Nose T, Shimizu H, Hara H, Minamida K, Miwa K, Ishizuka S. Combination of soya pulp and Bacillus coagulans lilac-01 improves intestinal bile acid metabolism without impairing the effects of prebiotics in rats fed a cholic acid-supplemented diet. British Journal of Nutrition, 116 (4) 603-610, 2016.

Joe GH, Andoh M, Shinoki A, Lang W, Kumagai Y, Sadahiro J, Okuyama M, Kimura A, Shimizu H, Hara H, Ishizuka S. Megalo-type α-1,6-glucosaccharides induce production of tumor necrosis factor α in primary macrophages via toll-like receptor 4 signaling. Biomedical Research (Tokyo), 37 (3) 179-186, 2016.

Shimizu H, Baba N, Nose T, Taguchi R, Tanaka S, Maseda H, Nomura N, Joe GH, Lee JY, Fukiya S, Yokota A, Ishizuka S, Miyazaki H. Activity of ERK regulates mucin 3 expression and is involved in undifferentiated Caco-2 cell death induced by 3-oxo-C12-homoserine lactone. Bioscience, Biotechnology, and Biochemistry, 79 (6) 937-942, 2015.

Hagio M, Shimizu H, Joe GH, Takatsuki M, Shiwaku M, Xu H, Lee JY, Fujii N, Hara H, Yokota A, Ishizuka S. Diet supplementation with cholic acid promotes intestinal epithelial proliferation in rats exposed to γ-radiation. Toxicology Letters, 232 (1) 246-252, 2015.

Taguchi R, Tanaka S, Joe GH, Maseda H, Nomura N, Ohnishi J, Ishizuka S, Shimizu H, Miyazaki H. Mucin 3 is involved in intestinal epithelial cell apoptosis via N-(3-oxododecanoyl)-L-homoserine lactone-induced suppression of Akt phosphorylation. American Journal of Physiology - Cell Physiology, 307 (2) C162-168, 2014.

Joe GH, Andoh M, Nomura M, Iwaya H, Lee JS, Shimizu H, Tsuji Y, Maseda H, Miyazaki H, Hara H, Ishizuka S. Acyl-homoserine lactones suppresses IEC-6 cell proliferation and increase permeability of isolated rat colon. Bioscience, Biotechnology, and Biochemistry, 78 (3) 462-465, 2014.

Laboratory Introduction

Thanks to the development of the science, our life span has been lengthened. The scientific development, however, caused social problems such as diseases related to the aging and non-communicable diseases (NCDs). Dietary habit is closely related to maintaining health and preventing NCDs.  Some elements of dietary can contribute to the prevention of NCDs by regulating immune cells such as macrophages. Through the process of storing, cooking and processing, our laboratory is investigating the unrevealed and unused marine bio-resources to use them as food resource. In addition, to propose new functional foods to prevent NCDs, we study the responses and mechanism of the immune system by experimenting on animals and cells. Most of the new discoveries in science usually begin with curiosity or interest, not difficult hypothesizes or principles. Students who are interested in food and dietary habit will be welcomed.