北海道大学 大学院水産科学研究院 大学院水産科学院 水産学部

英語サイトへ 北海道大学

*

准教授
平松　尚志
ひらまつ　なおし

  • 海洋応用生命科学部門　
  • 増殖生命科学科
  • 増殖生物学講座

オフィス

第2研究棟E302

メール

naoshi◎fish.hokudai.ac.jp
※「◎」を「@」に変更

電話

0138-40-8878

http://hlaboratory.g2.xrea.com/


研究課題
(1) 魚類の生殖生理に関する研究

(2) 海産魚類の養殖に関する研究

(3) ゲノム編集を用いた育種・生殖に関する研究

(4) 免疫生化学的技術を用いた水産技術の開発
代表的な業績
    


  1. Hiramatsu, N., Hara, A., Hiramatsu, K., Fukada, H., Weber, G.M., Denslow, N.D., Sullivan, C.V. 2002. Vitellogenin-derived yolk proteins of white perch, Morone Americana: purification, characterization, and vitellogenin-receptor binding. Biol. Reprod. 67(2): 655-667.
    2. 


  2. Hiramatsu, N., Chapman, R.W., Lindzey, J.K., Haynes, M.R., Sullivan, C.V. 2004. Molecular characterization and expression of vitellogenin receptor from white perch (Morone Americana). Biol. Reprod. 70(6): 1720-1730.
    3. 


  3. Hiramatsu, N., Cheek, A.O, Sullivan, C.V., Matsubara, T. and Hara, A. 2005. Vitellogenin as a biomarker for endocrine disruption: molecular and biochemical considerations. In: Biochemical and Molecular Biology of Fishes, pp.431-472, Vol. 6 Environmental Toxicology (T.W. Moon and T.P. Mommsen, editors).   Elsevier Science BV, Amsterdam, Netherlands.
    4. 


  4. Hiramatsu, N., Matsubara, T., Sullivan, C.V. and Hara, A. 2006. Multiple piscine vitellogenins: A critical use as biomarkers of exposure to estrogenic endocrine disruptors in aquatic environments. Mar. Biol. 149(1): 35-47.
    5. 


  5. Hiramatsu, N. 2010. Studies on yolk precursors and their receptors involved in fish oogenesis. Nippon Suisan Gakkaishi. 76(4): 613-616.
    6. 


  6. Reading B.J., Hiramatsu, N., Sullivan, C.V. 2011. Disparate binding of three types of vitellogenin to multiple forms of vitellogenin receptor in white perch. Biol. Reprod. 84(2): 392-399.
    7. 


  7. Hiramatsu, N., Luo, W., Reading, B.J., Sullivan, C.V., Mizuta, H., Ryu, Y.W., Nishimiya, O., Todo, T., Hara, A. 2013. Multiple ovarian lipoprotein receptors in teleosts. Fish Physiol. Biochem. 39(1): 29-32.
    8. 


  8. Reading, B.J., Hiramatsu, N., Schilling, J., Molloy, K.T., Glassbrook, N., Mizuta, H., Luo,W.S., Baltzegar, D.A., Williams, V.N., Todo, T., Hara, A., Sullivan, C.V. 2014. Lrp13 is a novel vertebrate lipoprotein receptor that binds vitellogenin in teleost fishes. J. Lipid Res. 55(11): 2287-2295.
    9. 


  9. Hiramatsu N., Todo T., Sullivan C.V., Schilling J., Reading B.J., Matsubara T., Ryu Y-W., Mizuta H., Luo W., Nishimiya O., Wu M., Mushirobira Y., Yilmazu O. and Hara A. (2015) Ovarian yolk formation in fishes: Molecular mechanisms underlying formation of lipid droprets and vitellogenin-derived yolk proteins. Gen. Comp. Endocrinol., 221:9-15.
    10. 


  10. Schilling, J., Nepomuceno, A.I. Planchart, A., Yoder, J.A., Kelly, R.M., Muddiman, D.C., Daniels, H.V., Hiramatsu, N. and Reading, B.J. (2015) Machine learning reveals sex-specific 17beta-estradiol-responsive expression patterns in white perch (Morone americana) plasma proteins. Proteomics. 15(15): 2678-2690.
    11. 


  11. Mushirobira, Y., Mizuta, H., Luo, Wenshu., Todo, T., Hara, A., Reading, B.J., Sullivan, C.V. and Hiramatsu. (2015) Molecular cloning and partial characterization of a low-density lipoprotein receptor-related protein 13 (Lrp13) involved in vitellogenin uptake in the cutthroat trout (Oncorhynchus clarki). Mol. Reprod. Dev. 82: 986-1000.
    12. 


  12. Hara, A., Hiramatsu, N. and Fujita, T. (2016) Vitellogenesis and choriogenesis in fishes. Fish. Sci., 82:187-202.
    13. 


  13. Nishimiya, O., Katsu, Y., Inagawa, H., Hiramatsu, N., Todo, T. and Hara, A. (2016) Molecular cloning and characterization of hagfish estrogen receptors. J. Steroid Biochem. Mol. Biol., DOI　http://dx.doi.org/doi:10.1016　/j.jsbmb.2016.06.004.
    14. 


  14. Kawasaki, T., Shimizu, Y., Mori, T., Hiramatsu, N., Todo, T. (2017) Development of artificial insemination techniques for viviparous black rockfish (Sebastes schlegelii). Aquacult. Sci., 65(1): 73-82.
    15. 


  15. Mizuta, H., Mushirobira, Y., Nagata, J., Todo, T., Hara, A., Reading, B.J., Sullivan, C.V., Hiramatsu, N. (2017). Ovarian expression and localization of clathrin (Cltc) compontnents in cutthroat trout, Oncorhynchus clarki: evidence for Cltc involvement in endocytosis of vitellogenin during oocyte growth. Comp. Biochem. Physiol. 212A: 24-34.
    16.
担当授業
学部

潜水調査実習（分担）

比較生理学（分担）

水圏生化学実験（分担）

水族生化学（分担）



大学院

増殖生物学特論Ⅰ（分担）

増殖生物学特論Ⅱ（分担）

水産科学汎論（分担）

増殖生物学演習（分担）

増殖生物学特別実験（分担）
略歴
平成5年3月　北海道大学水産学部水産増殖学科卒業

平成7年3月　北海道大学大学院水産学研究科　修士課程修了

平成10年3月　北海道大学大学院水産学研究科　博士課程修了

平成10年4月　日本学術振興会特別研究員　（PD）

平成11年1月　North Carolina State University (NCSU)　ポスドク研究員

平成12年10月　日本学術振興会特別研究員　（PD）

平成12年11月　NCSU Research Associate

平成13年11月　NCSU Senior Research Associate 

平成18年7月　国立大学法人北海道大学（助手）

平成19年4月　国立大学法人北海道大学（助教）

平成24年4月　国立大学法人北海道大学（准教授）
受賞
平成22 年3月　平成21年度日本水産学会水産学奨励賞　受賞
社会貢献
・科学論文雑誌審査員： 

Biochimica Biophysica Acta, Biology of Reproduction, Comparative Biochemistry and Physiology, Fish Physiology and Biochemistry, General and Comparative Endocrinology, Journal of Experimental Biology, Journal of Histochemistry and Cytochemistry, Fisheries Scienceなど各種科学ジャーナル



・各種大学開放事業企画・参加：

水産学部オープンキャンパス

水産学部公開講座

日本財団　海と日本プロジェクト

など各種事業
教員からのメッセージ
魚類は、哺乳類などに比べて太古に分化した脊椎動物であり、現在までに進化を重ねて、種毎に膨大な多様性を持つに至りました。生殖や成長機構も多岐に渡り、研究対象として大変面白い種も沢山います。個々の種の生殖メカニズムについて、同じ点や異なる点を探し、それらを明らかにして人の手で制御することで、養殖などの産業につなげます。魚の体内で働いている生殖や成長関連の遺伝子やタンパク質などを解析し、それを人為的に制御することで、未来の資源確保や食糧難に備える技術を開発していきたいと思います。

北海道大学研究者総覧システムへ


*

HIRAMATSU Naoshi

  • Associate Professor of Marine Life Science
  • Division of Marine Life Science
  • Department of Aquaculture Life Science

Office location

E302 Annex Building

Email

naoshi[at]fish.hokudai.ac.jp
※ change [at] to @

Phone

+81-138-40-8878

http://hlaboratory.g2.xrea.com/

Research Areas
Study on Fish Reproductive Physiology

Study on aquaculture development of marine fish

Study on breeding and reproduction using genome editing

Study on technology development using immunobiochemistry for fisheries sciences
Representative publications
    


  1. Hiramatsu, N., Hara, A., Hiramatsu, K., Fukada, H., Weber, G.M., Denslow, N.D., Sullivan, C.V. 2002. Vitellogenin-derived yolk proteins of white perch, Morone Americana: purification, characterization, and vitellogenin-receptor binding. Biol. Reprod. 67(2): 655-667.
    2. 


  2. Hiramatsu, N., Chapman, R.W., Lindzey, J.K., Haynes, M.R., Sullivan, C.V. 2004. Molecular characterization and expression of vitellogenin receptor from white perch (Morone Americana). Biol. Reprod. 70(6): 1720-1730.
    3. 


  3. Hiramatsu, N., Cheek, A.O, Sullivan, C.V., Matsubara, T. and Hara, A. 2005. Vitellogenin as a biomarker for endocrine disruption: molecular and biochemical considerations. In: Biochemical and Molecular Biology of Fishes, pp.431-472, Vol. 6 Environmental Toxicology (T.W. Moon and T.P. Mommsen, editors).   Elsevier Science BV, Amsterdam, Netherlands.
    4. 


  4. Hiramatsu, N., Matsubara, T., Sullivan, C.V. and Hara, A. 2006. Multiple piscine vitellogenins: A critical use as biomarkers of exposure to estrogenic endocrine disruptors in aquatic environments. Mar. Biol. 149(1): 35-47.
    5. 


  5. Hiramatsu, N. 2010. Studies on yolk precursors and their receptors involved in fish oogenesis. Nippon Suisan Gakkaishi. 76(4): 613-616.
    6. 


  6. Reading B.J., Hiramatsu, N., Sullivan, C.V. 2011. Disparate binding of three types of vitellogenin to multiple forms of vitellogenin receptor in white perch. Biol. Reprod. 84(2): 392-399.
    7. 


  7. Hiramatsu, N., Luo, W., Reading, B.J., Sullivan, C.V., Mizuta, H., Ryu, Y.W., Nishimiya, O., Todo, T., Hara, A. 2013. Multiple ovarian lipoprotein receptors in teleosts. Fish Physiol. Biochem. 39(1): 29-32.
    8. 


  8. Reading, B.J., Hiramatsu, N., Schilling, J., Molloy, K.T., Glassbrook, N., Mizuta, H., Luo,W.S., Baltzegar, D.A., Williams, V.N., Todo, T., Hara, A., Sullivan, C.V. 2014. Lrp13 is a novel vertebrate lipoprotein receptor that binds vitellogenin in teleost fishes. J. Lipid Res. 55(11): 2287-2295.
    9. 


  9. Hiramatsu N., Todo T., Sullivan C.V., Schilling J., Reading B.J., Matsubara T., Ryu Y-W., Mizuta H., Luo W., Nishimiya O., Wu M., Mushirobira Y., Yilmazu O. and Hara A. (2015) Ovarian yolk formation in fishes: Molecular mechanisms underlying formation of lipid droprets and vitellogenin-derived yolk proteins. Gen. Comp. Endocrinol., 221:9-15.
    10. 


  10. Schilling, J., Nepomuceno, A.I. Planchart, A., Yoder, J.A., Kelly, R.M., Muddiman, D.C., Daniels, H.V., Hiramatsu, N. and Reading, B.J. (2015) Machine learning reveals sex-specific 17beta-estradiol-responsive expression patterns in white perch (Morone americana) plasma proteins. Proteomics. 15(15): 2678-2690.
    11. 


  11. Mushirobira, Y., Mizuta, H., Luo, Wenshu., Todo, T., Hara, A., Reading, B.J., Sullivan, C.V. and Hiramatsu. (2015) Molecular cloning and partial characterization of a low-density lipoprotein receptor-related protein 13 (Lrp13) involved in vitellogenin uptake in the cutthroat trout (Oncorhynchus clarki). Mol. Reprod. Dev. 82: 986-1000.
    12. 


  12. Hara, A., Hiramatsu, N. and Fujita, T. (2016) Vitellogenesis and choriogenesis in fishes. Fish. Sci., 82:187-202.
    13. 


  13. Nishimiya, O., Katsu, Y., Inagawa, H., Hiramatsu, N., Todo, T. and Hara, A. (2016) Molecular cloning and characterization of hagfish estrogen receptors. J. Steroid Biochem. Mol. Biol., DOI　http://dx.doi.org/doi:10.1016　/j.jsbmb.2016.06.004.
    14. 


  14. Kawasaki, T., Shimizu, Y., Mori, T., Hiramatsu, N., Todo, T. (2017) Development of artificial insemination techniques for viviparous black rockfish (Sebastes schlegelii). Aquacult. Sci., 65(1): 73-82.
    15. 


  15. Mizuta, H., Mushirobira, Y., Nagata, J., Todo, T., Hara, A., Reading, B.J., Sullivan, C.V., Hiramatsu, N. (2017). Ovarian expression and localization of clathrin (Cltc) compontnents in cutthroat trout, Oncorhynchus clarki: evidence for Cltc involvement in endocytosis of vitellogenin during oocyte growth. Comp. Biochem. Physiol. 212A: 24-34.
    16.

HU Researcher Database