{"id":26824,"date":"2024-09-27T15:36:12","date_gmt":"2024-09-27T06:36:12","guid":{"rendered":"https:\/\/c-mng.cwh.hokudai.ac.jp\/www2.fish\/Root\/?p=26824"},"modified":"2024-09-27T15:36:12","modified_gmt":"2024-09-27T06:36:12","slug":"%e3%80%90%e3%83%97%e3%83%ac%e3%82%b9%e3%83%aa%e3%83%aa%e3%83%bc%e3%82%b9%e3%80%91%e3%82%a2%e3%83%9d%e3%82%ab%e3%83%ad%e3%83%86%e3%83%8e%e3%82%a4%e3%83%89%e3%81%8c%e5%85%8d%e7%96%ab%e7%b4%b0%e8%83%9e","status":"publish","type":"post","link":"https:\/\/c-mng.cwh.hokudai.ac.jp\/www2.fish\/Root\/infomation\/publicinfo\/26824","title":{"rendered":"\u3010\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u3011\u30a2\u30dd\u30ab\u30ed\u30c6\u30ce\u30a4\u30c9\u304c\u514d\u75ab\u7d30\u80de\u306b\u5bfe\u3057\u3066\u6297\u708e\u75c7\u4f5c\u7528\u3068Nrf2\u6d3b\u6027\u5316\u52b9\u679c\u3092\u793a\u3059\uff5e\u52d5\u7269\u306b\u304a\u3051\u308b\u30a2\u30dd\u30ab\u30ed\u30c6\u30ce\u30a4\u30c9\u306e\u751f\u7406\u7684\u610f\u7fa9\u306e\u89e3\u660e\u306b\u5411\u3051\u305f\u57fa\u790e\u77e5\u898b\u3068\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\uff5e\uff08\u6c34\u7523\u79d1\u5b66\u7814\u7a76\u9662\u3000\u52a9\u6559\u3000\u9ad8\u8c37\u76f4\u5df1\u3001\u6559\u6388\u3000\u7d30\u5ddd\u96c5\u53f2\u3001\u51c6\u6559\u6388\u3000\u5225\u5e9c\u53f2\u7ae0\u3001\u6c34\u7523\u79d1\u5b66\u9662\u4fee\u58eb\u8ab2\u7a0b2\u5e74\u3000\u5bae\u623f\u62d3\u751f\uff09"},"content":{"rendered":"

2024\u5e749\u670827\u65e5<\/p>\n

 <\/p>\n

\u30dd\u30a4\u30f3\u30c8<\/h3>\n

\u25cf\u30a2\u30dd-12′-\u30ab\u30d7\u30bd\u30eb\u30d3\u30ca\u30fc\u30eb\u304c\u708e\u75c7\u8a98\u5c0e\u3057\u305f\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u5bfe\u3057\u3066\u6297\u708e\u75c7\u4f5c\u7528\u3092\u793a\u3059\u3053\u3068\u3092\u767a\u898b\u3002
\n\u25cf\u30a2\u30dd-12′-\u30ab\u30d7\u30bd\u30eb\u30d3\u30ca\u30fc\u30eb\u306f\u7d30\u80de\u5185Nrf2\u3092\u6d3b\u6027\u5316\u3057\u3001\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u3002
\n\u25cf\u30a2\u30dd\u30ab\u30ed\u30c6\u30ce\u30a4\u30c9\u306e\u6d3b\u6027\u767a\u73fe\u306b\u30dd\u30ea\u30a8\u30f3\u9396\u5185\u90e8\u306e\u03b1,\u03b2-\u4e0d\u98fd\u548c\u30ab\u30eb\u30dc\u30cb\u30eb\u69cb\u9020\u304c\u95a2\u308f\u308b\u3053\u3068\u3092\u793a\u5506\u3002<\/p>\n

 <\/p>\n

\u6982\u8981<\/h3>\n

\u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u6c34\u7523\u79d1\u5b66\u7814\u7a76\u9662\u306e\u9ad8\u8c37\u76f4\u5df1\u52a9\u6559\u3001\u7d30\u5ddd\u96c5\u53f2\u6559\u6388\u3001\u5225\u5e9c\u53f2\u7ae0\u51c6\u6559\u6388\u3001\u540c\u5927\u5b66\u5927\u5b66\u9662\u6c34\u7523\u79d1\u5b66\u9662\u4fee\u58eb\u8ab2\u7a0b2\u5e74\u306e\u5bae\u623f\u62d3\u751f\u6c0f\uff08\u7814\u7a76\u5f53\u6642\uff09\u3001\u795e\u6238\u85ac\u79d1\u5927\u5b66\u306e\u5c71\u91ce\u7531\u7f8e\u5b50\u6559\u6388\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30a2\u30dd\u30ab\u30ed\u30c6\u30ce\u30a4\u30c9\u306e\u4e00\u7a2e\u3067\u3042\u308b\u30a2\u30dd-12′-\u30ab\u30d7\u30bd\u30eb\u30d3\u30ca\u30fc\u30eb\u304c\u3001\u514d\u75ab\u7d30\u80de\u306e\u4e00\u7a2e\u3067\u3042\u308b\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u5bfe\u3057\u3066\u6297\u708e\u75c7\u4f5c\u7528\u3092\u793a\u3059\u3068\u3068\u3082\u306b\u3001\u7d30\u80de\u5185\u9632\u5fa1\u30b7\u30b9\u30c6\u30e0\u3067\u3042\u308bnuclear factor erythroid 2-related factor 2\uff08Nrf2\uff09\u3092\u6d3b\u6027\u5316\u3059\u308b\u52b9\u679c\u3092\u898b\u3044\u3060\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u8907\u6570\u306e\u30a2\u30dd\u30ab\u30ed\u30c6\u30ce\u30a4\u30c9\u9593\u3067\u6bd4\u8f03\u3057\u305f\u3068\u3053\u308d\u3001\u4e0a\u8ff0\u306e\u6d3b\u6027\u767a\u73fe\u306b\u306f\u3001\u30dd\u30ea\u30a8\u30f3\u76f4\u9396\u5185\u90e8\u306e\u03b1,\u03b2-\u4e0d\u98fd\u548c\u30ab\u30eb\u30dc\u30cb\u30eb\u69cb\u9020\u304c\u95a2\u308f\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

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\u306a\u304a\u3001\u672c\u7814\u7a76\u6210\u679c\u306f\u30012024\u5e748\u670816\u65e5\uff08\u91d1\uff09\u516c\u958b\u306eArchives of Biochemistry and Biophysics<\/i>\u8a8c\u306b\u30aa\u30f3\u30e9\u30a4\u30f3\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u8ad6\u6587\u540d\uff1aApo-12′-capsorubinal exhibits anti-inflammatory effects and activates nuclear factor erythroid 2-related factor 2 in RAW264.7 macrophages\uff08\u30a2\u30dd-12′-\u30ab\u30d7\u30bd\u30eb\u30d3\u30ca\u30fc\u30eb\u306f\u3001RAW264.7\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u5bfe\u3057\u3066\u6297\u708e\u75c7\u53ca\u3073Nrf2\u6d3b\u6027\u5316\u4f5c\u7528\u3092\u793a\u3059\uff09<\/p>\n

 <\/p>\n

URL\uff1ahttps:\/\/doi.org\/10.1016\/j.abb.2024.110125<\/a><\/p>\n

 <\/p>\n

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