北海道大学 大学院水産科学研究院 大学院水産科学院 水産学部

英語サイトへ 北海道大学
助教
趙 佳賢
ジョ ガヒョン
  • 海洋応用生命科学部門 
  • 資源機能化学科
  • 水産食品科学講座
オフィス
管理研究棟514
メール
gahyun◎fish.hokudai.ac.jp
※「◎」を「@」に変更
電話
0138-40-5573
研究課題
食物成分による免疫応答の調節
未利用の海洋資源を利用した機能性食品の開発
代表的な業績
  1. Lee Y, Yoshitsugu R, Kikuchi K, Joe GH, Tsuji M, Nose T, Shimizu H, Hara H, Minamida K, Miwa K, Ishizuka S. Combination of soya pulp and Bacillus coagulans lilac-01 improves intestinal bile acid metabolism without impairing the effects of prebiotics in rats fed a cholic acid-supplemented diet. British Journal of Nutrition, 116 (4) 603-610, 2016.
  2. Joe GH, Andoh M, Shinoki A, Lang W, Kumagai Y, Sadahiro J, Okuyama M, Kimura A, Shimizu H, Hara H, Ishizuka S. Megalo-type α-1,6-glucosaccharides induce production of tumor necrosis factor α in primary macrophages via toll-like receptor 4 signaling. Biomedical Research (Tokyo), 37 (3) 179-186, 2016.
  3. Shimizu H, Baba N, Nose T, Taguchi R, Tanaka S, Maseda H, Nomura N, Joe GH, Lee JY, Fukiya S, Yokota A, Ishizuka S, Miyazaki H. Activity of ERK regulates mucin 3 expression and is involved in undifferentiated Caco-2 cell death induced by 3-oxo-C12-homoserine lactone. Bioscience, Biotechnology, and Biochemistry, 79 (6) 937-942, 2015.
  4. Hagio M, Shimizu H, Joe GH, Takatsuki M, Shiwaku M, Xu H, Lee JY, Fujii N, Hara H, Yokota A, Ishizuka S. Diet supplementation with cholic acid promotes intestinal epithelial proliferation in rats exposed to γ-radiation. Toxicology Letters, 232 (1) 246-252, 2015.
  5. Taguchi R, Tanaka S, Joe GH, Maseda H, Nomura N, Ohnishi J, Ishizuka S, Shimizu H, Miyazaki H. Mucin 3 is involved in intestinal epithelial cell apoptosis via N-(3-oxododecanoyl)-L-homoserine lactone-induced suppression of Akt phosphorylation. American Journal of Physiology - Cell Physiology, 307 (2) C162-168, 2014.
  6. Joe GH, Andoh M, Nomura M, Iwaya H, Lee JS, Shimizu H, Tsuji Y, Maseda H, Miyazaki H, Hara H, Ishizuka S. Acyl-homoserine lactones suppresses IEC-6 cell proliferation and increase permeability of isolated rat colon. Bioscience, Biotechnology, and Biochemistry, 78 (3) 462-465, 2014.
略歴
2012年 北海道大学大学院農学院応用生物科学専攻修士課程入学
2014年 同課程修了
2014年  北海道大学大学院農学院応用生物科学専攻博士後期課程入学
2016年  日本学術振興会特別研究員採用
2017年 北海道大学大学院農学院応用生物科学専攻博士後期課程修了
2017年  北海道大学大学院農学研究院学術研究員
受賞
2015年 The 6th International Conference on Food Factors-Poster Award受賞
2016年 日本農芸化学会・北海道支部-学生会員奨励賞受賞
教員からのメッセージ
科学の発達により寿命が延びた一方、生活習慣病や高齢化に伴う疾病が社会問題になっています。最近では健康維持に対する食事の関与が学問的に明らかになってきました。
食品成分の中には生体の免疫反応を調節することで疾患予防に寄与するものがあります。当研究室では、海洋生物資源に含まれている成分の生理作用や免疫反応への影響を調べ、最適な利用方法を研究しています。そして作用メカニズムを解明することで、生活習慣病の予防に貢献する新しい水産食品の提案を目標としています。科学の新発見は、通常、困難な仮説や原則ではなく、好奇心や興味から始まります。普段から食品や食習慣などに興味がある学生の皆さんを歓迎します。
北海道大学研究者総覧システムへ
JOE Gahyun
  • Assistant Professor of Aquaculture Genetics and Genomics
  • Division of Marine Life Science
  • Department of Marine Bioresources Chemistry
Office location
514 Main Building
Email
gahyun[at]fish.hokudai.ac.jp
※ change [at] to @
Phone
+81-138-40-5573
Research Areas
Modulation of immune responses by food ingredients 
Development of functional foods using underutilized fishery resources
Representative publications
  1. Lee Y, Yoshitsugu R, Kikuchi K, Joe GH, Tsuji M, Nose T, Shimizu H, Hara H, Minamida K, Miwa K, Ishizuka S. Combination of soya pulp and Bacillus coagulans lilac-01 improves intestinal bile acid metabolism without impairing the effects of prebiotics in rats fed a cholic acid-supplemented diet. British Journal of Nutrition, 116 (4) 603-610, 2016.
  2. Joe GH, Andoh M, Shinoki A, Lang W, Kumagai Y, Sadahiro J, Okuyama M, Kimura A, Shimizu H, Hara H, Ishizuka S. Megalo-type α-1,6-glucosaccharides induce production of tumor necrosis factor α in primary macrophages via toll-like receptor 4 signaling. Biomedical Research (Tokyo), 37 (3) 179-186, 2016.
  3. Shimizu H, Baba N, Nose T, Taguchi R, Tanaka S, Maseda H, Nomura N, Joe GH, Lee JY, Fukiya S, Yokota A, Ishizuka S, Miyazaki H. Activity of ERK regulates mucin 3 expression and is involved in undifferentiated Caco-2 cell death induced by 3-oxo-C12-homoserine lactone. Bioscience, Biotechnology, and Biochemistry, 79 (6) 937-942, 2015.
  4. Hagio M, Shimizu H, Joe GH, Takatsuki M, Shiwaku M, Xu H, Lee JY, Fujii N, Hara H, Yokota A, Ishizuka S. Diet supplementation with cholic acid promotes intestinal epithelial proliferation in rats exposed to γ-radiation. Toxicology Letters, 232 (1) 246-252, 2015.
  5. Taguchi R, Tanaka S, Joe GH, Maseda H, Nomura N, Ohnishi J, Ishizuka S, Shimizu H, Miyazaki H. Mucin 3 is involved in intestinal epithelial cell apoptosis via N-(3-oxododecanoyl)-L-homoserine lactone-induced suppression of Akt phosphorylation. American Journal of Physiology - Cell Physiology, 307 (2) C162-168, 2014.
  6. Joe GH, Andoh M, Nomura M, Iwaya H, Lee JS, Shimizu H, Tsuji Y, Maseda H, Miyazaki H, Hara H, Ishizuka S. Acyl-homoserine lactones suppresses IEC-6 cell proliferation and increase permeability of isolated rat colon. Bioscience, Biotechnology, and Biochemistry, 78 (3) 462-465, 2014.
Laboratory Introduction
Thanks to the development of the science, our life span has been lengthened. The scientific development, however, caused social problems such as diseases related to the aging and non-communicable diseases (NCDs). Dietary habit is closely related to maintaining health and preventing NCDs.  Some elements of dietary can contribute to the prevention of NCDs by regulating immune cells such as macrophages. Through the process of storing, cooking and processing, our laboratory is investigating the unrevealed and unused marine bio-resources to use them as food resource. In addition, to propose new functional foods to prevent NCDs, we study the responses and mechanism of the immune system by experimenting on animals and cells. Most of the new discoveries in science usually begin with curiosity or interest, not difficult hypothesizes or principles. Students who are interested in food and dietary habit will be welcomed.
HU Researcher Database