北海道大学 大学院水産科学研究院 大学院水産科学院 水産学部

英語サイトへ 北海道大学
准教授
別府 史章
べっぷ ふみあき
  • 海洋応用生命科学部門
  • 資源機能化学科
  • 生物資源化学講座
オフィス
管理研究棟521
メール
fbeppu◎fish.hokudai.ac.jp
※「◎」を「@」に変更
電話
0138-40-8802
研究課題
海洋生物に由来する生理活性成分の探索と健康機能性作用機構の解明
これら機能性成分の安全性と高度利用に関する基礎的研究
代表的な業績
Beppu F, Kondo H, Kasatani S, Aoki Y, Gotoh N. Quantitative analysis of Marine-Derived Tocopherol accumulation in tissues of mice fed salmon roe oil by high-performance liquid chromatography fluorescence method. J. Oleo Sci. accepted.

Beppu F, Li H, Yoshinaga K, Nagai T, Yoshinda A, Kubo A, Kanda J, Gotoh N. Dietary starfish oil prevents hepatic steatosis and hyperlipidemia in C57BL/6N mice fed high-fat diet. J. Oleo Sci. 66, 761-769 (2017).

Beppu F, Kawamatsu T, Yamatani Y, Nagai T, Yoshinaga K, Mizobe H, Yoshida A, Kubo A, Kanda J, Gotoh N. Comparison of catabolic rates of sn-1, sn-2, and sn-3 fatty acids in triacylglycerols using 13CO2 breath test in mice. J. Oleo Sci. 66, 85-91 (2017).

Beppu F, Konno K, Kawamatsu T, Nagai T, Yoshinaga K, Mizobe H, Kojima K, Watanabe H, Gotoh N. Comparison of catabolic rates of 13C-labeled palmitic acid bound to the alpha and beta positions of triacylglycerol using CO2 expired from mice. Eur. J. Lipid Sci. Tech. 117, 718-723 (2015).

Beppu F, Asanuma M, Kawamura Y, Nagai T, Yoshinaga K, Mizobe H, Kojima K, Kasatani S, Nagao K, Kubo A, Kanda J, Gotoh N. Trans-octadecenoic acid positional isomers have different accumulation and catabolism properties in mice. J. Oleo Sci. 64, 1159-1167 (2015).

Yoshinaga K, Sasaki K, Watanabe H, Nagao K, Inoue N, Shirouchi B, Yanagita T, Nagai T, Mizobe H, Kojima K, Beppu F, Gotoh N. Differential effects of triacylglycerol positional isomers containing n-3 series highly unsaturated fatty acids on lipid metabolism in C57BL/6J mice. J. Nutri. Biochem. 26, 57-63 (2015).

Beppu F, Nagai T, Yoshinaga K, Mizobe H, Kojima K, Gotoh N. Quantification of triacylglycerol molecular species in cocoa butter using high-performance liquid chromatography equipped with nano quantity analyte detector. J. Oleo Sci. 62, 789-794 (2013).

Beppu F, Hosokawa M, Yim MJ, Shinoda T, Miyashita K. Down-regulation of hepatic stearoyl-CoA desaturase-1 expression by fucoxanthin via leptin signaling in diabetic/obese KK-Ay mice. Lipids, 48, 449-455 (2013).

Beppu F, Hosokawa M, Niwano Y, Miyashita K. Effects of dietary fucoxanthin on cholesterol metabolism in diabetic/obese KK-Ay mice. Lipids Health Dis., 11, 112 (2012).

Hosokawa M, Miyashita T, Nishikawa S, Emi S, Tsukui T, Beppu F, Okada T, Miyashita K. Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-Ay mice. Arch. Biochem. Biophys., 504, 17-25 (2010).

Beppu F, Niwano Y, Sato E, Kohno M, Tsukui T, Hosokawa M, Miyashita K. In vitro and in vivo evaluation of mutagenicity of fucoxanthin (FX) and its metabolite fucoxanthinol (FXOH). J. Toxcol. Sci., 34, 693-698 (2009).

Beppu F, Niwano Y, Tsukui T, Hosokawa M, Miyashita K. Single and repeated oral dose toxicity study of fucoxanthin (FX), a marine carotenoid, in mice. J. Toxcol. Sci., 34, 501-510 (2009).

Beppu F, Niwano Y, Kyan R, Yasura K, Tamaki M, Nishino M, Midorikawa Y, Hamada H. Hypolipidemic effects of ethanol extracts of Citrus depressa and Annona atemoya, typical plant foodstuffs in Okinawa, Japan on KKAy mice fed with moderately high fat diet. Food Sci. Technol. Res., 15, 553-556 (2009).

Yasui Y, Suzuki R, Kohno H, Miyamoto S, Beppu F, Hosokawa M, Miyashita K, Tanaka T. 9trans,11trans conjugated linoleic acid inhibits the development of azoxymethane-induced colonic aberrant crypt foci in rats. Nutr. Cancer, 59, 82-91 (2007).

Beppu F, Hosokawa M, Tanaka L, Kohno H, Tanaka T, Miyashita K. Potent inhibitory effect of trans9, trans11 isomer of conjugated linoleic acid on the growth of human colon cancer cells. J. Nutri. Biochem., 17, 830-836 (2006).
略歴
2004年3月 北海道大学水産学部海洋生物資源化学科 卒業
2004年4月 北海道大学大学院 水産科学院海洋応用生命科学専攻 博士前期課程 
2006年4月‐2009年7月 サニーヘルス株式会社
2009年4月 北海道大学大学院 水産科学院海洋応用生命科学専攻 博士後期課程
2012年4月 北海道大学大学院 水産科学院海洋応用生命科学専攻 博士研究員
(2011年4月‐2013年2月 日本学術振興会 特別研究員)
2013年3月 東京海洋大学大学院学術研究院 食品生産科学部門 助教
(2014年5月‐2015年3月 マサチューセッツ州立大学 訪問研究員)
2018年4月  北海道大学大学院水産科学研究院 海洋生物資源化学分野 准教授
教員からのメッセージ
海洋生物や海藻に含まれる脂質成分による生理活性作用について、生活習慣病の予防効果に注目して研究しています。水産物に含まれるどの化合物が、どこの組織/細胞で、どのような作用機構で健康維持に役立つのか。これを明らかにするために、毎日地道に実験を繰り返す根性がある人、一緒に研究しましょう。
北海道大学研究者総覧システムへ
BEPPU Fumiaki
  • Associate Professor
  • Division of Marine Life Science
  • Department of Marine bioresources Chemistry
Office location
521 Main Building
Email
fbeppu[at]fish.hokudai.ac.jp
※ change [at] to @
Phone
+81-138-40-8802
Research Areas
Bioactive food compounds from marine organisms
Safety evaluation and application of marine bioactive compounds
Representative publications
Beppu F, Kondo H, Kasatani S, Aoki Y, Gotoh N. Quantitative analysis of Marine-Derived Tocopherol accumulation in tissues of mice fed salmon roe oil by high-performance liquid chromatography fluorescence method. J. Oleo Sci. accepted.

Beppu F, Li H, Yoshinaga K, Nagai T, Yoshinda A, Kubo A, Kanda J, Gotoh N. Dietary starfish oil prevents hepatic steatosis and hyperlipidemia in C57BL/6N mice fed high-fat diet. J. Oleo Sci. 66, 761-769 (2017).

Beppu F, Kawamatsu T, Yamatani Y, Nagai T, Yoshinaga K, Mizobe H, Yoshida A, Kubo A, Kanda J, Gotoh N. Comparison of catabolic rates of sn-1, sn-2, and sn-3 fatty acids in triacylglycerols using 13CO2 breath test in mice. J. Oleo Sci. 66, 85-91 (2017).

Beppu F, Konno K, Kawamatsu T, Nagai T, Yoshinaga K, Mizobe H, Kojima K, Watanabe H, Gotoh N. Comparison of catabolic rates of 13C-labeled palmitic acid bound to the alpha and beta positions of triacylglycerol using CO2 expired from mice. Eur. J. Lipid Sci. Tech. 117, 718-723 (2015).

Beppu F, Asanuma M, Kawamura Y, Nagai T, Yoshinaga K, Mizobe H, Kojima K, Kasatani S, Nagao K, Kubo A, Kanda J, Gotoh N. Trans-octadecenoic acid positional isomers have different accumulation and catabolism properties in mice. J. Oleo Sci. 64, 1159-1167 (2015).

Yoshinaga K, Sasaki K, Watanabe H, Nagao K, Inoue N, Shirouchi B, Yanagita T, Nagai T, Mizobe H, Kojima K, Beppu F, Gotoh N. Differential effects of triacylglycerol positional isomers containing n-3 series highly unsaturated fatty acids on lipid metabolism in C57BL/6J mice. J. Nutri. Biochem. 26, 57-63 (2015).

Beppu F, Nagai T, Yoshinaga K, Mizobe H, Kojima K, Gotoh N. Quantification of triacylglycerol molecular species in cocoa butter using high-performance liquid chromatography equipped with nano quantity analyte detector. J. Oleo Sci. 62, 789-794 (2013).

Beppu F, Hosokawa M, Yim MJ, Shinoda T, Miyashita K. Down-regulation of hepatic stearoyl-CoA desaturase-1 expression by fucoxanthin via leptin signaling in diabetic/obese KK-Ay mice. Lipids, 48, 449-455 (2013).

Beppu F, Hosokawa M, Niwano Y, Miyashita K. Effects of dietary fucoxanthin on cholesterol metabolism in diabetic/obese KK-Ay mice. Lipids Health Dis., 11, 112 (2012).

Hosokawa M, Miyashita T, Nishikawa S, Emi S, Tsukui T, Beppu F, Okada T, Miyashita K. Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-Ay mice. Arch. Biochem. Biophys., 504, 17-25 (2010).

Beppu F, Niwano Y, Sato E, Kohno M, Tsukui T, Hosokawa M, Miyashita K. In vitro and in vivo evaluation of mutagenicity of fucoxanthin (FX) and its metabolite fucoxanthinol (FXOH). J. Toxcol. Sci., 34, 693-698 (2009).

Beppu F, Niwano Y, Tsukui T, Hosokawa M, Miyashita K. Single and repeated oral dose toxicity study of fucoxanthin (FX), a marine carotenoid, in mice. J. Toxcol. Sci., 34, 501-510 (2009).

Beppu F, Niwano Y, Kyan R, Yasura K, Tamaki M, Nishino M, Midorikawa Y, Hamada H. Hypolipidemic effects of ethanol extracts of Citrus depressa and Annona atemoya, typical plant foodstuffs in Okinawa, Japan on KKAy mice fed with moderately high fat diet. Food Sci. Technol. Res., 15, 553-556 (2009).

Yasui Y, Suzuki R, Kohno H, Miyamoto S, Beppu F, Hosokawa M, Miyashita K, Tanaka T. 9trans,11trans conjugated linoleic acid inhibits the development of azoxymethane-induced colonic aberrant crypt foci in rats. Nutr. Cancer, 59, 82-91 (2007).
HU Researcher Database